Hanzlik Said Electricians Were At Work At His Bar

AlexanderJoe, há 4 anos

Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally defined docking domains (DDs) at their Nand C termini to ensure correct assembly into functional multi protein complexes. Here we report a fundamentally different mechanism for subunit assembly in trans AT modular PKSs at the junction between ketosynthase (KS) and dehydratase (DH) domains.

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